World Conference on Interventional Radiology (WCIO) and Best of ASCO 2008
June 22 - 25, 2008  |  Hyatt Regency Century Plaza  |  Los Angeles, CA
 
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STM 2007 Annual Meeting
May 13–17 2007
Washington Hilton, Washington, DC


SUNDAY, MAY 13, 2007

12:00 pm - 6:00 pm   Registration
1:00 pm - 5:00 pm   Poster Set-up
6:00 pm - 8:30 pm   STM Poster Session – Introductory Social

MONDAY, MAY 14, 2007

7:00 am - 8:00 am   Continental Breakfast
7:30 am - 8:30 am   Refresher Course: TEMPERATURE MATTERS: VASCULAR AND IMMUNOLOGICAL EFFECTS OF HEAT
Chair: Elizabeth Repasky
8:30 am - 10:00 am   General Session I: BASIC BIOLOGY OF COMBINED MODALITY THERAPIES
Chair: Michael Borrelli
 
  1. Understanding Tumor Physiology to Optimize Thermal Therapy in Combination with Radiation and Experimental Therapeutics – Robert Griffin
    View Presentation Slides (14mb)

  2. Mechanisms and Strategies for Clinical Applications of Heat-Induced Radiosensitization – Joe Roti Roti
    View Presentation Slides (1.5mb)

  3. Novel Approaches to Combining Thermal Ablation with Gene Therapy, Chemotherapy & Radiotherapy to Achieve Local & Loco-Regional Tumor Control – Michael Borrelli

  4. Extracellular Hsp70 in Tumor Therapy – Stuart Calderwood
10:00 am - 10:30 am   Coffee Break (Exhibit Hall)
10:30 am - 12:00 pm   General Session II: Biology: Biological Modifiers of Thermal Response
Moderators: Sharon Evans & Robert Griffin
  1 Role of Oxidative Stress in Hyperthermia-induced Apoptosis
D. A. Averill-Bates, Z. Wang, A. Bettaieb;
Université du Québec à Montréal, Montréal, PQ, CANADA.

2 Hyperthermia Enhances the Anti-angiogenic Effect of Manganese Porphyrin Mimetic of Superoxide Dismutase
I. Jackson, M. Burdick, I. Batinic-Haberle, S. Poulton, Y. Zhao, M. W. Dewhirst, Z. Vujaskovic;
Duke University Medical Center, Durham, NC.

3 Nucleophosmin's Role in the Cellular Response to Heat Shock
R. P. VanderWaal;
Washington University Sch. Med, St. Louis, MO.


4 Mitochondrial Density May Explain Metabolic Heterogeneity
D. B. Leeper1, M. G. Pocceschi1, C. F. Lavorgna1, C. W. Storck1, R. A. Coss1, M. D., O'Hara1, J. Lum2;
1Thomas Jefferson University, Philadelphia, PA, 2University of Pennsylvania, Philadelphia, PA.
View Presentation Slides (1mb)

5 Sensitization of Human Melanoma Xenogafts to Cisplatin by Inhibitors of Respiration and Monocarboxylic Acid Transporters
J. D. Glickson1, D. S. Nelson1, R. Zhou1, L. Z. Li1, D. B. Leeper2;
1University of Pennsylvania, Philadelphia, PA, 2Thomas Jefferson University, Philadelphia, PA.

6 Thermal Therapy: A Potential Modality to Overcome Restrictions on Lymphocyte Infiltration of the Tumor Microenvironment
D. T. Fisher, Q. Chen, J. Skitzki, J. Muhitch, K. Clancy, W. Wang, E. A. Repasky, S. S. Evans;
Roswell Park Cancer Institute, Buffalo, NY.

7 Systemic Thermal Therapy Improves Effector Cell Trafficking to Sites of Tumor and Clinical Outcome
J. Skitzki, Q. Chen, D. Fisher, J. Muhitch, W. Wang, E. Repasky, S. Evans;
Roswell Park Cancer Institute, Buffalo, NY.

8 Control of Type 1 diabetes in non-obese diabetic mice by mild hyperthermia involves thermal activation of NK cells and a blockade of ß-islet-destroying leukocytes
M. L. Capitano, B. E. Dayanc, J. R. Ostberg, E. A. Repasky;
Roswell Park Cancer Institute, Buffalo, NY.

9 Evaluation of Thermally Ablated Tumor Margins: Distinguishing Heat-Fixed from Viable Cells in Histologic Sections
L. J. Hennings, P. Novak, R. J. Griffin, P. Corry, B. C. Stack, E. G. Moros, Y. Kaufmann, S. Ferguson, P. Spring, G. Shafirstein;
University of Arkansas for Medical Sciences, Little Rock, AR.
12:00 pm - 1:00 pm   Lunch Break & Poster Viewing (Exhibit Hall & Poster Room)
1:00 pm - 3:00 pm   STM/WCIO Joint Concurrent Session I: WORKING TOWARDS THE NEXT GENERATION OF THERAPEUTIC DEVICES AND TECHNIQUES
STM Co-Chair: William Nau
WCIO Co-Chair: Philippe L. Pereira
 
  1. Advancing Thermal Therapy Technology & Delivery: Where We Are and Where We Should Be Heading – Thomas Ryan

  2. New Techniques & Strategies for High-Intensity Focused Ultrasound Thermal Therapy – Nathan McDannold

  3. New/Novel Microwave & RF Ablation – Damian Dupuy

  4. Percutaneous & Catheter- Based High-Intensity Ultrasound for Conformal Thermal Therapy – Chris Diederich

  5. MR-Guided Laser Induced Thermal Ablative Therapy – Jason Stafford
3:00 pm - 3:45 pm   Refreshment Break (Exhibit Hall)
3:30 pm - 5:30 pm   STM/WCIO Joint Concurrent Session II: ADVANCED IMAGING FOR MONITORING, CONTROL & ASSESSMENT
STM Co-Chair: Nathan McDannold
WCIO Co-Chair: Lawrence Schwartz
 
  1. MRI-based Temperature Mapping for Monitoring Thermal Ablation – Andrew Webb

  2. Ultrasound Imaging Methods for Interventional Procedures – Flemming Forsberg

  3. Closed Loop Feedback Control of Thermal Ablation Using MRI-Based Thermotherapy” - Chrit Moonen

  4. Advanced Molecular Imaging in Image Guided Intervention – Heiko Schoder

  5. MRI-based Feedback Control of Prostate Thermal Ablation with Transurethral Ultrasound Applicator – Rajiv Chopra

  6. Molecular Imaging of Cancer in the Post-Genomic Era – Michael Kuo
6:00 pm - 7:30 pm   Welcome Reception
7:30 pm - 9:00 pm   Topic Related Symposium - Colorectal Carcinoma – (Invited Drug Companies Only)
Chair: Wells Messersmith
7:30 pm - 9:00 pm   Topic Related Symposium - Exploring Multi-Disciplinary Advances in Colorectal Cancer Treatment
Presented by Sanofi-aventis
7:30 pm - 9:00 pm   Industry Symposium – How to Get your RFA Business Cooking
Made possible by a grant from Valleylab Energy Based Medical Systems

TUESDAY, MAY 15, 2007

7:00 am - 5:30 pm   Registration
7:00 am - 8:00 am   Continental Breakfast (Exhibit Hall)
7:30 am - 8:30 am   Refresher Course: PHYSICS OF THERMAL THERAPY DELIVERY
Chair: Jeff Hand
View Presentation Slides (12.5mb)
8:30 am - 10:00 am   General Session III: CLINICAL AND BASIC SCIENCE OF CRYOTHERAPY
Chair: John Bischof
 
  1. Mechanisms of Cryoinjury and Their Enhancement – Jahn G. Baust

  2. Computerized Planning of Cryotherapy: From 3D Image Reconstruction to Intra-Operative Planning – Yoed Rabin

  3. Imaging in Tumor Ablation: Comparison of Cryosurgery with Other Ablation Modalities – Gary Onik

  4. Clinical Prostate Cryosurgery: Critical Review – Jeff Cohen

  5. Cryo-Chemotherapy: The use of Molecular Adjuvants in Cryosurgery – John Bischof
10:00 am - 10:30 am   Coffee Break (Exhibit Hall)
10:30 am - 12:00 pm   General Session IV: SELECTED ABSTRACTS
  Physics I: Heating Devices & Monitoring Techniques
Moderators: Jason Stafford & Oana Craciunescu

10. Very High Temperature Thermal Ablation of Tumors and Margins.
G. Shafirstein, P. Novak, R. J. Griffin, L. Hennings, Y. Kaufmann, S. L. Ferguson, E. R. Siegel, B. C. Stack, P. Spring, P. Corry, E. G. Moros;
University of Arkansas for Medical Sciences, Little Rock, AR.

11 Switched-mode microwave ablation: A simple and robust method of power delivery
C. L. Brace, P. F. Laeseke, L. A. Sampson, D. W. van der Weide, F. T. Lee, Jr;
University of Wisconsin, Madison, WI.
View Presentation Slides (3.6mb)

12 Liver radiofrequency thermo-ablation under MR-Temperature imaging: Is the thermal dose a reliable and precise indicator of tissue ablation?
B. Quesson1, O. Seror2, M. Lepetit-Coiffé 1, B. Lebail3, B. Denis De Senneville1, C. Moonem1, H. Trillaud1;
1IMF/CNRS, Université Bordeaux 2, Bordeaux, FRANCE, 2Hôpital Jean Verdier, AP-HP, Bondy, FRANCE, 3Service d'anatomopathologie/Hôpital Universitaire Pellegrin, Bordeaux, FRANCE.
View Presentation Slides (4.8mb)

13 Selective Heating in Advanced Breast Tumor Model at 915MHz
P. F. Turner1, M. Hagmann1, L. Wu2;
1BSD Medical Corporation, Salt Lake City, UT, 2Michigan State University, East Lansing, MI.
View Presentation Slides (4.3mb)

14 Optimization of Polygonal Shaped Multifed Slot Antennas for Custom Conformal Microwave Arrays in Hyperthermia Treatment of Superficial Diseases
P. F. Maccarini, P. R. Stauffer;
Duke University, Durham, NC.

15 Innovations in Technology to Target Heating in Head and Neck Hyperthermia
M. M. Paulides, J. F. Bakker, P. P. Jansen, P. C. Levendag, C. van der Zee, G. C. van Rhoon;
Erasmus MC Daniel den Hoed, Rotterdam, THE NETHERLANDS.
View Presentation Slides (11.8mb)

16 Factors affecting Accurate Thermometry during Ultrasound Thermal Therapies
G. R. ter Haar, H. Morris, J. McLaughlan, I. Rivens;
Institute of Cancer Research, Sutton, Surrey, UNITED KINGDOM.

17 Role of Digital Infrared Imaging (DII) in Estimating Response of Breast Cancer Patients with Chest Wall (CW) Recurrence Treated with Thermally Sensitive Liposomes Containing Doxorubicin (ThermoDoxTM;TDox) and Hyperthermia (HT)
O. I. Craciunescu, E. L. Jones, Z. Vujaskovic, V. Liotcheva, P. R. Stauffer, O. Mbibi, M. W. Dewhirst, K. L. Blackwell;
Duke University Medical Center, Durham, NC.
View Presentation Slides (20mb)

18 Microwave Thermal Imaging in Conjunction with Focused Ultrasound Therapy: Phantom Experimental Results
P. M. Meaney;
Dartmouth College, Hanover, NH.
View Presentation Slides (9.8mb)
12:00 pm – 1:00 pm   Lunch Break & Poster Viewing
(Exhibit Hall & Poster Room)
1:00 pm - 3:00 pm   STM/WCIO Joint Concurrent Session III: BIOLOGICAL BASIS OF PERCUTANEOUS AND TRANSARTERIAL ONCOLOGY THERAPIES
STM Co-Chair: Peter Corry
WCIO Co-Chair: S. Nahum Goldberg
 
  1. Biology of Hyperthermia – Peter M. Corry

  2. Thermal Ablation Biology – S. Nahum Goldberg

  3. Biological Aspects of Transarterial Therapy – Jeff Geschwind

  4. The Role of Immunology in Hyperthermic Therapy of Cancer – Elizabeth Repasky

  5. Combined Modality Therapy – Mark W. Dewhirst
3:00 pm - 3:45 pm   Refreshment Break (Exhibit Hall)
3:30 pm - 5:30 pm   STM/WCIO Joint Concurrent Session IV: COMBINING SYSTEMIC, REGIONAL & LOCAL THERAPIES FOR IMPROVED CLINICAL OUTCOME
STM Co-Chair: Mark Hurwitz
WCIO Co-Chair: Yuman Fong
 
  1. Combined Chemo – Embolization/Ablation – Riccardo Lencioni

  2. Combined Resection/Ablation – Ronnie Poon

  3. Combined Liposomal Chemo/Ablation and/or Hyperthermia – Brad Wood

  4. Combined XRT/Hormonal Therapy/Hyperthermia or Ablation – Mark Hurwitz

  5. Combined RFA & Regional Chemotherapy – Nancy E. Kemeny
6:00 pm - 7:00 pm   Robinson Lecture
Barriers and Breakthroughs in the Evolution of Thermal Therapy
Paul Stauffer, Duke University
View Presentation Slides (35.9mb)
6:00 pm - 9:00 pm   Industry Symposium
Evidence-Based Medicine in the Medical Device World: Where Are We and Where do We Need to Go?
Made possible by a grant from Boston Scientific Corporation
8:00 pm - 11:00 pm   Robinson Dinner

WEDNESDAY, MAY 16, 2007

7:00 am - 5:00 pm   Registration
7:00 am - 8:00 am   Continental Breakfast
7:30 am - 8:30 am   Refresher Course: PRACTICAL ISSUES REGARDING HOW TO SET-UP AND RUN A THERMOTHERAPY TRIAL
Chair: Ellen Jones
8:30 am - 10:00 am   General Session V: NANO-THERMAL THERAPEUTICS (LIPOSOMES, NANOSCALE ADJUVANTS, HEAT ACTIVATION)
Chair: Mark Dewhirst
 
  1. Use of Ferromagnetic Fluid for Thermal Therapy – Andreas Jordan

  2. Nanotherapeutics for Enhancing Thermal Therapy of Cancer – John Bischof

  3. Iron Platinum Containing Nanoparticles for Thermochemotherapy – Steve Barry

  4. Development of Novel Thermally Sensitive Liposomal Drug Delivery Systems for Hyperthermia – David Needham
10:00 am - 10:30 am   Coffee Break (Exhibit Hall)
10:30 am - 12:00 pm   General Session VI
Physics 2: Physics 2: Image Guided Therapy, Control & Assesment
Moderators: Robert J. McGough & Peter Novak
  19 Cryoablation of the lung: Does ventilation effect ablation zone size? A pilot study in the porcine model
J. L. Hinshaw, P. Laeseke, C. Brace, L. Sampson, N. Durick, F. T. Lee, Jr;
University of Wisconsin School of Medicine and Public Health, Madison, WI.

20 Simultaneous MR temperature imaging and radiofrequency ablation of liver tumor: A pilot study
O. Seror1, M. Lepetit Coiffé2, B. Denis De Senneville3, H. Laumonié4, H. Trillaud4, C. Moonen5, B. Quesson5; 1Hôpital Jean Verdier, AP-HP, Bondy, FRANCE, 2IMF/ ERT CNRS / Université Bordeaux 2, Bordeaux, FRANCE, 3IMF/ ERT CNRS / Université Bordeaux 2, Bordeaux, FRANCE, 4Service de Radiologie / Hôpital Universitaire St André, Bordeaux, FRANCE, 5IMF / ERT CNRS / Université Bordeaux 2, Bordeaux, FRANCE.
View Presentation Slides (3mb)

21 Feasibility of Mega-Voltage-CT (MVCT) Treatment Planning for Concurrent SURLAS Thermal Therapy and Irradiation with Helical Tomotherapy
J. A. Penagaricano, P. Novak, R. J. Griffin, E. G. Moros; University of Arkansas For Medical Sciences, Little Rock, AR.
View Presentation Slides (14.3mb)

22 Monitoring And Guidance Of Radio-Frequency And Ultrasound Ablation With Real-Time Ultrasound Elastography
R. J. McGough1, J. Hamilton2, C. Mosser1, R. Thakur1, C. Morrison1;
1Michigan State University, East Lansing, MI, 2Pixel Velocity Inc., Ann Arbor, MI.
View Presentation Slides (3.3mb)

23 Noninvasive Temperature Monitoring Using Change in Backscattered Energy for Clinically Relevant Heating Scenarios
B. L. Straube, R. M. Arthur, J. W. Trobaugh;
Washington University, St. Louis, MO.
View Presentation Slides (12.2mb)

24 Quantitative Analysis of Thermally Ablated TTC-stained Animal Breast Tissue
P. Novák, L. Hennings, Y. Kaufmann, S. Ferguson, E. Moros, R. J. Griffin, P. Spring, P. Corry, and G. Shafirstein;
University of Arkansas for Medical Sciences, Little Rock, AR

25 Optimization of HIFU Scanning Parameters
R. Roemer, A. Payne;
University of Utah, Salt Lake City, UT.

26 Effective Cancer Therapy Design Through the Integration of Nanotechnology and Computational Treatment Planning Models
M. N. Rylander1, Y. Feng2, D. Carroll3, R. Kraft4;
1Virginia Tech, Blacksburg, VA, 2University of Texas at Ausin, Ausin, TX, 3Wake Forest University, Winston-Salem, NC, 4Wake Forest Medical Center, Winston-Salem, NC.

27 To Kill or Not to Kill: On Fundamental Issues of Thermal Therapies in Cancer Treatment
Y. Feng1, M. N. Rylander2, I. Babuska1, K. R. Diller1, J. T. Oden1;
1The University of Texas at Austin, Austin, TX, 2Virginia Polytechnic and State University, Blacksburg, VA.

12:00 pm - 1:30 pm   STM Business Meeting & Lunch
1:30 pm - 3:00 pm   General Session VII: THERMAL THERAPIES INCORPORATING RADIATION, SURGERY AND/OR DRUGS
CO-Chairs: Don Thrall and Terry Herman
 
  1. Surgery Combined with RF Ablation in Breast Cancer – V. Suzanne Klimberg

  2. Chest Wall Recurrence of Breast Cancer Treated using Hyperthermia and Radiation – Krystyna D. Kiel
    View Presentation Slides (8.5mb)

  3. Chest Wall Recurrence of Breast Cancer Treaded Using Hyperthermia, Radiation and Doxil – Vassilis Kouloulias

  4. Chest Wall Recurrence of Breast Cancer Treated with Hyperthermia and Thermally Sensitive Liposomes (ThermoDox) – Zelijko Vujaskovic
    View Presentation Slides (15.1mb)

3:00 pm - 3:30 pm   Refreshment Break (Exhibit Hall)
3:30 pm - 5:00 pm   General Session VIII
Clinical: Clinical Trials & Dose Effects
Moderators: Zeljko Vujaskovic & Brad Wood
  28. A Comparison of Thermal Dose Requirements for Radiofrequency, Laser, and Microwave Tumor Ablation
P.M. Mertyna1, M. Ahmed1, M. W. Dewhirst 2, Z. Liu 1, W. Goldberg3, S. N. Goldberg1;
1BIDMC, Boston, MA, 2Duke University Medical Center, Durham, NC, 3CUNY, Queens, NY.

29 Cryotherapy for Benign and Cancerous Breast Tumors: The Importance of Understanding Cytotoxic Isotherms
P. J. Littrup1, D. Bouwman2, L. Freeman-Gibb1, B. Adam 1;
1Karmanos Cancer Center, Detroit, MI, 2Dept of Surgery, Wayne State University, Detroit, MI.
View Presentation Slides (8.8mb)

30 The Importance of Thermal Dose: A Phase I/II Study of Neoadjuvant Liposomal Doxorubicin, Paclitaxel, and Hyperthermia in Locally Advanced Breast Cancer
D. W. Kim, K. L. Blackwell, Z. Vujaskovic, M. W. Dewhirst, P. R. Stauffer, V. Liotcheva, E. Jones;
Duke University Medical Center, Durham, NC.
View Presentation Slides (1.2mb)

31 Simultaneous Radiation Therapy and Hyperthermia in the Elective Treatment of Subclinical Disease in High Risk Breast Carcinoma: A Phase III Comparison of Post Treatment Normal Tissue Effects in Heated and Unheated Portions of the Chest Wall.
R. J. Myerson, W. Straube, M. Taylor, I. Zoberi, J. Luly, E. Moros;
Washington University School of Medicine, St Louis, MO.

32 Combined Chemoembolization & Radio Frequency Ablation for Local Control of Liver Tumors
Mikhail CSS Higgins, Jeffrey I. Mondschein, S. William Stavropoulos, Catherine M. Tuite, Timothy Wi Clark, Michael C. Soulen;
University of Pennsylvania, PA

33 An Update of a Phase II Clinical Trial using Fever-Range Whole-Body Thermal Therapy (FR-WB-TT) + Cisplatin (CIS) + Gemcitabine (GEM) + Metronomic, Low-Dose Interferon-a (IFN-a) for Inoperable or Metastatic Pancreas Cancer
J. M. Bull, G. L. Scott, G. Figueroa, S. Tompte, T. Danczak, F. R. Strebel, D. H. Oliver, M. D. Redwine, S. M. Koch;
The University of Texas Medical School at Houston, Houston, TX.

34 LAPAROSCOPIC RENAL CRYOABLATION FOR TUMORS LESS THAN 3.5 CM
T. J. Polascik, J. M. Mayes, I. Nosnik, V. Mouraviev;
Duke Medical University Center, Durham, NC
View Presentation Slides (1.2mb)

35 Efficacy of intraperitoneal drug delivery (IPDD) combined with external capacitative hyperthermia as palliation therapy in patients with recurrent epithelial ovarian cancer (ROC): a phase II clinical study.
G. Fiorentini, P. Giovanis, D. Dacomo, M. Vaira, A. Toscano, M. De Simone;
San Giuseppe Hospital ASL 11, Empoli (Florence), ITALY.
View Presentation Slides (4mb)

36 Hyperthermia in the Treatment of Gynecologic Cancer: A Review of the Cervix Cancer Experience
E. Jones, Z. Vujaskovic, O. Craciunescu, L. Havrilesky, A. Secord, P. Stauffer, M. Dewhirst;
Duke University, Durham, NC.
View Presentation Slides (500k)

5:00 pm   Adjourn
6:00 pm - 9:00 pm   Industry Symposium
Radiofrequency Ablation (RFA) of Breast Cancer Lumpectomy Cavities: Tissue-Based Validation of a Technique Intended to Increase Negative Margins After Breast Conservation Surgery
Made possible by a grant from Angiodynamics, Inc.

SELECTED POSTERS

    P1 Reduced-order temperature optimization using virtual sources
K. CHENG, V. Stakhursky, S. Das;
DUKE UNIVERSITY, Durham, NC.

P2 Hyperthermia cancer treatment using magnetic resonance temperature images for feedback control
K. CHENG, V. Stakhursky, S. Das;
DUKE UNIVERSITY, Durham, NC.

P3 A Noninvasive Temperature Measurement Regarding the Heating Applicator Based on a Reentrant Cavity
Y. Ishihara1, Y. Endo1, N. Wadamori1, H. Ohwada2;
1Nagaoka University of Technology, Nagaoka, JAPAN, 2Niigata Sangyo University, Kashiwazaki, JAPAN.

P4 A Heating Applicator Based on a Reentrant Cavity with Optimized Local Heating Characteristics
Y. Ishihara, Y. Minegishi, N. Wadamori;
Nagaoka University of Technology, Nagaoka, JAPAN.

P5 Fully Automated Water Degassing Procedure for Acoustical Characterization Measurements of Ultrasound Hyperthermia Equipment
P. Novák, E. G. Moros;
University of Arkansas for Medical Sciences, Little Rock, AR.

P6 Drift Correction For Non-Invasive MRI Based Temperature Dose Monitoring During Hyperthermia Treatment
V. L. Stakhursky1, J. MacFall2, O. Arabe1, K. T. Kelly1, B. J. Soher2, P. R. Stauffer1, S. K. Das1;
1Duke University Medical Center, Radiation Oncology, Durham, NC, 2Duke University Medical Center, Radiology, Durham, NC.

P7 Tumors Secreting Glucose-Regulated Protein 170 (grp170) As Cell-Based Cancer Vaccines
J. Subjeck, H. Arnouk, X. Wang, B. Hylander, E. Zynda, L. Kazim;
Roswell Park Cancer Inst, Buffalo, NY.

P8 Long-duration, Fever-range, Thermal Therapy Increases Oxaliplatin-induced Cell Kill, Cellular Platinum Uptake, and Formation of Platinum-DNA Adducts in Breast Cancer Cells
F. R. Strebel1, Z. H. Siddik2, W. Deng1, R. W. Rowe1, J. M. Bull1;
1University of Texas Medical School at Houston, Houston, TX, 2M.D. Anderson Cancer Center, Houston, TX.

P9 Control of SAR Distribution within a Cylindrical Annular Phased Array (APA) Applicator
Z. Li1, W. T. Joines1, P. R. Stauffer2, V. L. Stakhursky2, O. A. Arabe2, P. F. Maccarini2, S. K. Das2;
1Electrical and Computer Engineering, Duke University, Durham, NC, 2Department of Radiation Oncology, Duke University School of Medicine, Durham, NC.

P10 Local and Systemic Hyperthermia in Surgical Patients
Andrea Kurz, M.D.
Departments of Anaesthesiology, University of Berne, Switzerland / The Cleveland Clinic Foundation, Ohio

P11 Cardiac catheter ablation: Convective cooling affects lesion size during cryo and radiofrequency ablation in opposite directions
T. A. Pilcher, J. Saul, D. Haemmerich;
Medical University of South Carolina, Charleston, SC.

P12 Mechanisms and Strategies for Clinical Applications of Heat-Induced Radiosensitization
J. L. Roti Roti, J. L. Roti Roti;
Washington University Sch. Med, St. Louis, MO.

P13 Systemic Thermal Therapy Induces Intratumoral Vascular Expression of ICAM-1 Through an Interleukin-6-dependent Mechanism.
L. Zhou, Q. Chen, J. Skitzki, J. Muhitch, W. Wang, E. Repasky, H. Baumann, S. Evans;
Roswell Park Cancer Institute, Buffalo, NY.

P14 Ultrasound Transducer for Microbubble Cavitations in a Microscopic Window Chamber
P. Novák, E. Moros, M. Borrelli;
University of Arkansas for Medical Sciences, Little Rock, AR.

P15 Thermal Sensitization of Human Melanoma Cells Grown at Low pH by Lonidamine and MIBG
R. A. Coss, D. B. Leeper, V. Patel, Y. Ning, C. W. Storck;
Thomas Jefferson University, Philadelphia, PA.

P16 Fever-range thermal stress suppresses inflammatory cytokine production in LPS-activated peritoneal macrophages
C. Lee, E. Repasky;
Roswell Park Cancer Institute, Buffalo, NY.

P17 Electrode array to minimize blood loss during liver resection: in-vivo results in a porcine model
D. J. Schutt, A. P. O'Rourke, J. A. Will, J. G. Webster, D. M. Mahvi, D. Haemmerich;
Medical University of South Carolina, Charleston, SC.

P18 Microprobe Measurements of the Directive Properties of Tissue Conductivity Predict RF Ablation Shape in Perfused Pig Liver
M. Yi1, R. L. Mahajan2, R. J. Podhajsky3;
1Department of Mechanical Engineering, University of Colorado, Boulder, CO, 2Institute for Critical Technologies and Applied Sciences, Virginia Tech, Blacksburg, VA, 3Valleylab / Tyco Healthcare, Boulder, CO

P19 Changes in Tumor Vascularity and Radiation Response after Thermal Ablation
R. J. Griffin1, C. W. Song2, G. Shafirstein1, P. Corry1, E. Moros1, P. Novak1, B. W. Williams2;
1University of Arkansas for Medical Sciences, Little Rock, AR, 2University of Minnesota, Minneapolis, MN.

P20 A Phase I Pharmacokinetic/Pilot Study of Fever Range Whole Body Hyperthermia (FR-WBH) and Doxil® in Patients with Advanced Malignant Disease: An Update.
W. Kraybill, K. Odunsi, J. Kane, M. Fakih, L. Pendyala, A. Litwin, A. Proefrock, K. O'Leary, P. Wallace, W. Greco, D. Driscoll, D. Lawrence, S. Evans, E. A. Repasky;
Roswell Park Cancer Institute, Buffalo, NY.

P21 Indispensable role of IL-6-activated STAT3 in promoting ICAM-1-dependent lymphocyte trafficking during fever-range thermal stress
T. D. VARDAM, Q. Chen, J. Skitzki, M. Appenheimer, W. Wang, M. Ernst, H. Baumann, S. Evans;
ROSWELL PARK CANCER INSTITUTE, BUFFALO, NY.

P22 RFTA of small breast cancer: 3T MRI monitoring of effectiveness
G. Manenti, E. Cossu, O. Buonomo, C. Pistolese, F. Bolacchi, E. Bonanno, G. Simonetti;
POLICLINICO TOR VERGATA, ROME, ITALY.

P23 Tumor Vascular Composition and pO2 During Daily Heatings at 41-43 °C: Elucidating Physiological and Cellular Mechanisms of Vascular Thermotolerance
R. P. Dings1, M. Loren1, C. W. Song1, E. Moros2, P. Novak2, P. Corry2, R. Griffin2;
1University of Minnesota, Minneapolis, MN, 2University of Arkansas for Medical Sciences, Little Rock, AR.

P24 Transition State Theory Tissue Damage Prediction: Alternatives to Arrhenius
A. K. Ward, G. J. Collins;
Colorado State University, Fort Collins, CO.

P25 Fever-range Whole Body Hyperthermia Does Not Increase Metastasis of 4T1 Mouse Mammary Tumors
H. L. Enriquez, A. Sen, E. A. Repasky, B. L. Hylander;
Roswell Park Cancer Institute, Buffalo, NY.

P26 Indocyanine green enhanced photothermal ablation of glioma cells
J. A. Myhill, G. Shafirstein, M. Kokoska, M. J. Borrelli;
University of Arkansas for Medical Sciences, Little Rock, AR.

P27 Determining How Mild Thermal Stress Enhances NK cell Mediated Tumor Cytotoxicity
B. E. Dayanc, J. R. Ostberg, M. Yuan, E. A. Repasky;
Roswell Park Cancer Institute, Buffalo, NY.

P28 Manipulating the Thermal Environment to Restore the Immune System Following Radiation Exposure
T. Mace*, M. Capitano*, A. Kisailus, W. Jaggernauth, E. Repasky;
Roswell Park Cancer Institute, Buffalo, NY.

P29 Application of High-Intensity Focused Ultrasound in Resection of Abdominal Solid Organs
V. Zderic1, G. O'Keefe2, J. Foley3, S. Vaezy3;
1Dept. of Electrical Engineering, The George Washington University, Washington, DC, 2Dept. of Surgery, University of Washington, Seattle, WA, 3Dept. of Bioengineering, University of Washington, Seattle

P30 An even milder whole body hyperthermia protocol controls tumor growth and increases functional tumor blood vessels and leukocyte infiltration
A. J. Kisailus, M. Grimm, S. Evans, W. Kraybill, E. Repasky;
Roswell Park Cancer Institute, Buffalo, NY.

P31 The Effects of Fever-Range Whole Body Hyperthermia on Macrophage Infiltration in Tumors
S. Van Note, A. Kisailus, B. Hylander, J. Ostberg, S. Evans, E. Repasky;
Roswell Park Cancer Institute, Buffalo, NY.

P32 Coupling Effect of Pulsatile Blood Flow and Thermal Relaxation Time during Thermal Surgery
T. Shih1, T. Horng2, W. Lin3;
1China Medical University, Taichung, TAIWAN, 2Feng Chia University, Taichung, TAIWAN, 3National Taiwan University, Taipei, TAIWAN.

P33 Use of Fat-Water Phase Difference to Stabilize MR Thermometry
C. Wyatt, B. Soher, J. MacFall;
Duke University Medical Center, Durham, NC.

P34 Prostate Thermal Therapy with High Intensity Transurethral Ultrasound: The Impact of Pelvic Bone Heating on Treatment Delivery
J. H. Wootton, A. B. Ross, C. J. Diederich;
UCSF, San Francisco, CA.

P35 The Complication Rate After Cryosurgical Ablation for Clinically Localized Prostate Cancer Using Third Generation Cryotechnology
V. Mouraviev, J. M. Mayes, I. Nosnik, T. J. Polascik;
Duke Medical University Center, Durham, NC.

P36 Recovery of Urinary Function is Quicker after Cryosurgery Compared to Surgical Prostatectomy
V. Mouraviev, J. M. Mayes, L. Sun, J. W. Moul, T. J. Polascik;
Duke Medical University Center, Durham, NC.

P37 Financial Comparative Analysis of Minimally Invasive Surgery to Open Surgery for Small Renal Tumors Less than 3.5 cm: A Single Experience
T. J. Polascik, J. M. Mayes, I. Nosnik, V. Mouraviev;
Duke Medical University Center, Durham, NC.

P38 Thermobrachytherapy Surface Applicators for Chestwall Recurrence
J. L. Schlorff1, P. R. Stauffer2, P. F. Maccarini2, T. Juang3, A. J. Milligan1;
1Bionix Development Corporation, Paoli, PA, 2Duke University Medical Center, Durham, NC, 3University of California San Francisco, San Francisco, CA.

P39 Financial Comparative Analysis of Cryosurgical Ablation of the Prostate and Surgical Prostatectomy for Clinically Localized Prostate Cancer: Single Institutional Experience
V. Mouraviev, J. M. Mayes, I. Nosnik, T. J. Polascik;
Duke Medical University Center, Durham, NC.

P40 Prostate Cancer Laterality as a Rational for the Clinical Application of Focal Ablative Therapy: An Analysis of 1184 Prostatectomy Specimens Clinically Localized Prostate Cancer: Single Institutional Experience
T. P. Polascik, J. M. Mayes, L. Sun, J. F. Madden, D. G. George, P. Febbo, J. W. Moul, and V. Mouraviev;
Duke Medical University Center, Durham, NC

P41 Tumor Laterality does not Predict Biochemical Prostate Cancer Recurrence After Radical Prostatectomy
V. Mouraviev, J. M. Mayes, L. Sun, J. F. Madden, D. J. George, P. Febbo, J. W. Moul, T. J. Polascik;
Duke Medical University Center, Durham, NC.

P42 A heat shock protein binding receptor, scavenger receptor-A, negatively regulates antitumor immunity.
X. Wang, J. Facciponte, J. Subjeck, E. Repasky;
Roswell Park Cancer Institute, Buffalo, NY.

P43 Taking Advantage of the Differential Thermoregulatory Abilities of Normal and Tumor Vasculature to Selectively Improve Delivery of Therapies and Effector Immune Cells to Tumors
A. Sen, J. Schueckler, S. Hockwater, J. Spernyak, R. Mazurchuk, B. Hylander, E. Repasky; Roswell Park Cancer Institute, Buffalo, NY.

P44 Measurements of the 2D SAR Maps in 4 Antenna Mini Annular Phased Array Applicator
V. L. Stakhursky1, O. A. Arabe1, P. R. Stauffer1, P. F. Maccarini1, Z. Li2, W. T. Joines2, S. K. Das1;
1Duke University Medical Center, Radiation Oncology, Durham, NC, 2Duke University, Electrical and Computing Engineering, Durham, NC.

P45 Practical Application of Rate Mediated Ablation Size Estimation
C. Ladtkow;
Valleylab, Boulder, CO.

P46 Novel Magnetic Fluid Hyperthermia System Leading to the Focused Heating of Tumors.
T. O. Tasci1, I. Vargel2, A. Arat3, E. Guzel4, P. Korkusuz4, E. Atalar5;
1University of Utah, Salt Lake City, UT, 2Kirikkale University School of Medicine, Kirikkale, TURKEY, 3Baylor College of Medicine, Houston, TX, 4Hacettepe University School of Medicine, Ankara, TURKEY, 5Johns Hopkins University School of Medicine, Baltimore, MD.

P47 Evaluation of Interstitial Ultrasound for Thermal Ablation of Human Uterine Myomas
W. Nau1, C. Diederich1, J. Simko1, X. Chen1, C. Burdette2, A. Jacoby1;
1University of California, San Francisco, San Francisco, CA, 2Acoustic MedSystems, Inc., Champaign, IL.

P48 Percutaneous Cryotherapy of Soft Tissue (Non-organ) Metastases: Potential for Local Control with Low Morbidity as a Flexible Adjunct to Systemic Therapy
D. Cyriac2 , P. J. Littrup1, H. Aoun2, S. Nakat2, B. Adam1;
1Karmanos Cancer Center, Detroit, MI, 2Wayne State University, Detroit, MI.

P49 Model Predictive Control of Phased Array HIFU treatments
A. Blankenspoor, J. Moellmer, N. Todd, C. Goodrich, M. Skliar, D. Parker, D. Christensen, R. Roemer;
University of Utah, Salt Lake City, UT: S. Roell and F. Steinmeyer, Siemens Medical Solutions, Inc. Erlangen, Germany

P50 Nanoparticle enhanced laser induced thermal therapy in liver: simulation, phantom and ex vivo investigation of feasibility
R. Stafford1, A. M. Elliot1, A. Shetty1, J. Wang2, J. D. Hazle1;
1The University of Texas M. D. Anderson Cancer Center, Houston, TX, 2Nanospectra Biosciences, Inc., Houston, TX.

P51 Rapid & Effective Thermal Ablation at Temperatures Between 41oC and 45oC Using Aliphatic Ablation Sensitizers
M. J. Borrelli, H. R. Williams, L. J. Bernock;
University of Arkansas for Medical Sciences, Little Rock, AR

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